The risks below apply to both diagnostic and interventional procedures. The frequency of each risk is higher when coronary intervention is performed. "Common" means it occurs in more than 1 in 100 patients; "uncommon" in 1–10 per 1,000; "rare" in fewer than 1 per 1,000.
Bruising & Haematoma
Discolouration and swelling at the wrist or groin access site is the most frequent minor complication. Blood may collect under the skin forming a firm lump (haematoma), which can be tender for several days. It resolves on its own in the majority of cases without requiring treatment.
Significant Bleeding
Heavier bleeding at the access site may require prolonged manual pressure, a compression device, or a closure device placed in the artery. Bleeding requiring a blood transfusion is very uncommon. The radial (wrist) approach carries a substantially lower bleeding risk than the femoral (groin) approach.
Access Artery Injury
Damage to the radial artery at the wrist or the femoral artery at the groin can cause narrowing, spasm, or a false aneurysm (pseudoaneurysm). Radial artery occlusion occurs in up to 2–5% of radial procedures but the hand circulation is almost always maintained through other vessels and rarely causes symptoms.
Coronary Artery Dissection
A dissection is a tear in the inner lining of the coronary artery, caused by catheter, guidewire, or balloon contact. Small dissections at the edge of an intervention site are common and usually benign. Larger dissections that impair blood flow require prompt treatment to prevent a heart attack.
Coronary Artery Perforation
A perforation is a small hole in the coronary artery wall, allowing blood to leak into the space around the heart (pericardium). This can cause the heart to be compressed — a serious but manageable complication. Perforations are most commonly caused by guidewires during complex intervention in calcified arteries.
Heart Attack (Myocardial Infarction)
A heart attack during the procedure can be caused by a coronary artery closing suddenly due to spasm, dissection, thrombosis, or material displaced from a plaque. Small procedure-related myocardial infarctions — detectable only on blood tests — are more common than clinically significant events, particularly during complex intervention in calcified arteries.
Stroke or TIA
A stroke can occur if a blood clot or fragment of atherosclerotic plaque dislodges during catheter manipulation and travels to a brain artery. The risk is very low in elective procedures but is higher in patients with atrial fibrillation, significant aortic atherosclerosis, or previous stroke. A transient ischaemic attack (TIA) produces similar symptoms that resolve fully within 24 hours.
Emergency Surgery
In rare circumstances — most commonly a large coronary perforation or uncontrolled dissection that cannot be managed with catheter-based techniques — emergency referral for coronary artery bypass surgery is required. This is an extremely unusual outcome of modern catheter-based procedures but remains a possibility that must be disclosed.
Death
Death as a direct result of elective cardiac catheterisation is very rare in carefully selected patients. The risk is significantly higher in patients having emergency procedures, those with severely impaired cardiac function, or those with very complex anatomy. In the elective setting the risk is approximately one in a thousand for diagnostic procedures and somewhat higher when complex intervention is performed.
Contrast Reaction & Kidney Effects
Iodine-based contrast dye used in all coronary angiography procedures can cause an allergic reaction, ranging from mild flushing and nausea to, very rarely, a severe anaphylactic reaction. In patients with pre-existing kidney disease, contrast dye can temporarily worsen kidney function. All patients at risk are identified beforehand and protective measures taken.
Abnormal Heart Rhythm
Brief disturbances of heart rhythm are common during catheter manipulation inside the heart and are usually transient and harmless. Occasionally a sustained arrhythmia — such as ventricular fibrillation — requires treatment. ECG is monitored continuously throughout every procedure and a defibrillator is always immediately available.
Radiation Exposure
Coronary angiography uses ionising radiation (X-rays) to produce images. The dose varies with procedure complexity but is typically 2–10 mSv — equivalent to several months to a few years of natural background radiation. For a single procedure this represents a very small theoretical increase in lifetime cancer risk. Radiation exposure is minimised at all times. Angiography is not performed during pregnancy.